![]() All patients should be tested for tuberculosis before starting on tofacitinib. The most common side effects of tofacitinib are upper respiratory tract infections, headache, diarrhea, and nasopharyngitis. Blood tests will be used to monitor for increases in cholesterol or liver enzymes and for reductions in blood cell counts while taking tofacitinib. Some patients will start to see improvement within a few weeks, but it may take several months to take full effect. Tofacitinib should not be given in combination with another biologic drug or other potent immunosuppressants such as azathioprine or mycophenolate. Tofacitinib may be used alone or in combination with methotrexate or other disease modifying antirheumatic drugs (DMARDs). People with moderate to severe kidney or liver problems should take a lower dose. You may take tofacitinib with or without food. ![]() Tofacitinib is a pill that is taken either as 5 mg twice a day (Xeljanz) or as 11 mg once per day (Xeljanz XR). This medication is commonly used after methotrexate and tumor necrosis factor inhibitors. JAKs play a role in joint inflammation in RA, which can cause pain, swelling, and stiffness. It works by blocking enzymes called Janus kinases (JAKs). Tofacitinib Citrate (Xeljanz) is an oral drug used to treat adults with moderate to severe active rheumatoid arthritis (RA), active psoriatic arthritis, ankylosing spondylitis, moderate to severe ulcerative colitis, and children ages 2 and older with active polyarticular juvenile idiopathic arthritis.
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